METHYL-THIOURACIL AND THIOURACIL AS ANTITHYROID DRUGS

Thiouracil in Thyrotoxicosis

Enzymatic synthesis of thiouracil riboside and thiouracil desoxyriboside.

In a survey of various substrates for pyrimidine nucleoside synthesis, it was noted that inorganic orthophosphate was released when 2-thiouracil and desoxyribose-l-phosphate were incubated together with thymidine phosphorylase (1). This finding, taken as a fairly certain indication of nucleoside synthesis, has now been fully substantiated by isolation and characterization of crystalline thioura...

Physiological effects of thiouracil and similar drugs on sheep.

T HE discovery of thiouracil and its derivatives as potent substances for inhibiting the function of the thyroid gland (Astwood, ~943; Astwood et al., I94 ~ and McGinty and Bywater, I94g) has made it possible to study some of the effects of limiting thyroid functions. A detailed report indicative of the effects of these substances on the thyroid gland is given by Astwood et al. (~943). They rep...

Biosynthesis of a Thiouracil Pheomelanin in Embryonic Pigment Cells Exposed to Thiouracil*

[Z-W]Thiouracil and [%]thiouracil are incorporated into the melanin of chick retinal pigment epithelium incubated in vitro. This synthesis of a thiouracil pheomelanin (thiolcuntaining melanin) can be used to measure the rate of melanin synthesis in living cells. Thiouracil incorporation is dependent on tyrosinase activity: incorporation is inhibited by phenylthiourea, a tyrosinase inhibitor, an...

Juvenile thyrotoxicosis treated with thiouracil.

Prepubertal thyrotoxicosis is a condition of some rarity and comparatively few childhood cases have so far been recorded in the literature where the drug thiouracil has been used in treatment. A review of six cases so treated was published by Williams and Janney (1947). The present case provides a suitable example both of the clinical picture and the response to treatment. Atkinson (1938) in a ...